Publications
Ethan S Sokol, Yu-Xiong Feng, Dexter X Jin, Minu D Tizabi, Daniel H Miller, Malkiel A Cohen, Sandhya Sanduja, Ferenc Reinhardt, Jai Pandey, Daphne A Superville, Rudolf Jaenisch, Piyush B Gupta.
Proceedings of the National Academy of Sciences of the United States of America. (2017) Apr; 114(16) 4153-4158 PubMed
Cancer cells exhibit clonal diversity in phenotypic plasticity.
Robert Austin Mathis, Ethan S Sokol, Piyush B Gupta.
Open biology. (2017) Feb; 7(2) PubMed
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.
Peter Tsvetkov, Ethan Sokol, Dexter Jin, Zarina Brune, Prathapan Thiru, Mahmoud Ghandi, Levi A Garraway, Piyush B Gupta, Sandro Santagata, Luke Whitesell, Susan Lindquist.
Proceedings of the National Academy of Sciences of the United States of America. (2017) Jan; 114(2) 382-387 PubMed
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.
Eric J Solís, Jai P Pandey, Xu Zheng, Dexter X Jin, Piyush B Gupta, Edoardo M Airoldi, David Pincus, Vladimir Denic.
Molecular cell. (2016) Jul; 63(1) 60-71 PubMed
Growth of human breast tissues from patient cells in 3D hydrogel scaffolds.
Ethan S Sokol, Daniel H Miller, Anne Breggia, Kevin C Spencer, Lisa M Arendt, Piyush B Gupta.
Breast cancer research : BCR. (2016) Mar; 18(1) 19 PubMed
Perturbation-expression analysis identifies RUNX1 as a regulator of human mammary stem cell differentiation.
Ethan S Sokol, Sandhya Sanduja, Dexter X Jin, Daniel H Miller, Robert A Mathis, Piyush B Gupta.
PLoS computational biology. (2015) Apr; 11(4) e1004161 PubMed
Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.
Yarden Katz, Feifei Li, Nicole J Lambert, Ethan S Sokol, Wai-Leong Tam, Albert W Cheng, Edoardo M Airoldi, Christopher J Lengner, Piyush B Gupta, Zhengquan Yu, Rudolf Jaenisch, Christopher B Burge.
eLife. (2014) Nov; 3() e03915 PubMed
De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling.
Catherine A Del Vecchio, Yuxiong Feng, Ethan S Sokol, Erik J Tillman, Sandhya Sanduja, Ferenc Reinhardt, Piyush B Gupta.
PLoS biology. (2014) Sep; 12(9) e1001945 PubMed
Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation.
Sarah Phillips, Aleix Prat, Maja Sedic, Theresa Proia, Ania Wronski, Sohini Mazumdar, Adam Skibinski, Stephanie H Shirley, Charles M Perou, Grace Gill, Piyush B Gupta, Charlotte Kuperwasser.
Stem cell reports. (2014) May; 2(5) 633-47 PubMed
Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells—Probe 2.
Leigh C. Carmody, Andrew Germain, Barbara Morgan, Lynn VerPlank, Cristina Fernandez, Yuxiong Feng, Jose R. Perez, Sivaraman Dandapani, Benito Munoz, Michelle Palmer, Eric S. Lander, Piyush B. Gupta, Stuart L. Schreiber.
National Center for Biotechnology Information (US) Bethesda (MD) . Probe Reports from the NIH Molecular Libraries Program. ( 2010 ) PubMed
Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.
Yu-Xiong Feng, Ethan S Sokol, Catherine A Del Vecchio, Sandhya Sanduja, Jasper H L Claessen, Theresa A Proia, Dexter X Jin, Ferenc Reinhardt, Hidde L Ploegh, Qiu Wang, Piyush B Gupta.
Cancer discovery. (2014) Jun; 4(6) 702-15 PubMed
The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition.
Yu-Xiong Feng, Ethan S Sokol, Piyush B Gupta.
Molecular & cellular oncology. () ; 1(2) e961822 PubMed
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment.
Adam Skibinski, Jerrica L Breindel, Aleix Prat, Patricia Galván, Elizabeth Smith, Andreas Rolfs, Piyush B Gupta, Joshua Labaer, Charlotte Kuperwasser.
Cell reports. (2014) Mar; 6(6) 1059-72 PubMed
Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3.
Leigh Carmody, Andrew Germain, Barbara Morgan, Lynn VerPlank, Cristina Fernandez, Yuxiong Feng, Jose Perez, Sivaraman Dandapani, Benito Munoz, Michelle Palmer, Eric S. Lander, Piyush B. Gupta, Stuart L. Schreiber.
National Center for Biotechnology Information (US) Bethesda (MD) . Probe Reports from the NIH Molecular Libraries Program. ( 2010 ) PubMed
Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 1.
Leigh Carmody, Andrew Germain, Barbara Morgan, Lynn VerPlank, Cristina Fernandez, Erin Forbeck, Amal Ting, Yuxiong Feng, Jose Perez, Sivaraman Dandapani, Benito Munoz, Michelle Palmer, Eric Lander, Piyush B. Gupta, Stuart L. Schreiber.
National Center for Biotechnology Information (US) Bethesda (MD) . Probe Reports from the NIH Molecular Libraries Program. ( 2010 ) PubMed
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Andrew R Germain, Leigh C Carmody, Partha P Nag, Barbara Morgan, Lynn Verplank, Cristina Fernandez, Etienne Donckele, Yuxiong Feng, Jose R Perez, Sivaraman Dandapani, Michelle Palmer, Eric S Lander, Piyush B Gupta, Stuart L Schreiber, Benito Munoz.
Bioorganic & medicinal chemistry letters. (2013) Mar; 23(6) 1834-8 PubMed
Protein array patterning by diffusive gel stamping.
Mekhail Anwar, Piyush B Gupta, Raja Palaniapan, Paul Matsudaira.
PloS one. (2012) ; 7(10) e46382 PubMed
Identification of a selective small molecule inhibitor of breast cancer stem cells.
Andrew R Germain, Leigh C Carmody, Barbara Morgan, Cristina Fernandez, Erin Forbeck, Timothy A Lewis, Partha P Nag, Amal Ting, Lynn VerPlank, Yuxiong Feng, Jose R Perez, Sivaraman Dandapani, Michelle Palmer, Eric S Lander, Piyush B Gupta, Stuart L Schreiber, Benito Munoz.
Bioorganic & medicinal chemistry letters. (2012) May; 22(10) 3571-4 PubMed
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.
Piyush B Gupta, Christine M Fillmore, Guozhi Jiang, Sagi D Shapira, Kai Tao, Charlotte Kuperwasser, Eric S Lander.
Cell. (2011) Aug; 146(4) 633-44 PubMed
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection.
Sagi D Shapira, Irit Gat-Viks, Bennett O V Shum, Amelie Dricot, Marciela M de Grace, Liguo Wu, Piyush B Gupta, Tong Hao, Serena J Silver, David E Root, David E Hill, Aviv Regev, Nir Hacohen.
Cell. (2009) Dec; 139(7) 1255-67 PubMed